Feasibility of wait and watch strategy for patients with high-risk factors after endoscopic submucosal dissection for early colorectal cancer
10.3760/cma.j.issn115396-20210713-00261
- VernacularTitle:早期结直肠癌内镜黏膜下剥离术后伴有高危因素患者的等待观察策略可行性
- Author:
Xiaomu ZHAO
1
;
Lei NIU
;
Jin WANG
;
Lan JIN
;
Zhongtao ZHANG
Author Information
1. 首都医科大学附属北京友谊医院普通外科 100050
- Keywords:
Colorectal neoplasms;
Watchful waiting;
Surgical procedures, operative;
Endoscopic submucosal dissection
- From:
International Journal of Surgery
2021;48(11):764-768,f4
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the feasibility of wait and watch treatment for patients with high-risk pathology factors after endoscopic submucosal dissection (ESD) for early colorectal cancer.Methods:From December 2012 to June 2020, 104 patients, including 62 males and 42 females, aged from 31 to 89 years old, with the average of (59.5±10.8) years with early colorectal cancer after ESD operation were selected from the Department of General Surgery, Beijing Friendship Hospital, Capital Medical University. According to the follow-up treatment, the patients were divided into two groups: the additional surgical resection group and the wait and watch group. The measurement data of normal distribution were shown by mean standard deviation, the comparison between groups adopted t test, and the comparison of counting data between groups adopted χ2 test. The types of pathological high-risk factors after ESD were compared between the two groups, and the overall survival (OS) and progression free survival (PFS) of the two groups were compared by Log-Rank test. Results:The median follow-up time was(40.6±15.3) months. The OS and PFS of the additional surgical resection group and the wait and watch group were 100.0% vs 98.4% and 90.7% vs 90.2%, respectively, and there was no statistically significant difference between the two groups (OS: χ2=0.875, P=0.35; PFS: χ2=0.017, P=0.80). Conclusion:The wait and watch strategy is expected to be one of the follow-up choices for some patients with high risk factors after ESD operation for early colorectal cancer.
