Research progress of hyaluronidase in malignant tumors
10.3760/cma.j.cn115396-20210918-00373
- VernacularTitle:透明质酸酶在恶性肿瘤中的研究进展
- Author:
Weiquan WANG
1
;
De HE
Author Information
1. 广东医科大学研究生院，湛江 524023
- Keywords:
Hyaluronoglucosaminidase;
Neoplasms;
Gene expression;
Mechanism of action
- From:
International Journal of Surgery
2021;48(10):705-710
- CountryChina
- Language:Chinese
-
Abstract:
Hyaluronidase is a type of glycosidase that can specifically degrade hyaluronic acid (HA). There are mainly 6 types, among which hyaluronidase-1 ( HYAL-1) and hyaluronidase-2 ( HYAL-2) has a more in-depth study and has different roles in different tumors. HYAL-1 and HYAL-2 have the potential to be used as biomarkers for the diagnosis of malignant tumors, especially in common malignant tumors such as colorectal cancer, pancreatic cancer, bladder cancer, and prostate cancer. Compared with traditional biomarkers, they have higher specificity and sensitivity. Other studies have shown that Hyaluronidase can assist chemotherapy drugs to enhance the efficacy of drugs. hyaluronidase plays both a role in promoting cancer and a role in suppressing cancer in malignant tumors. This article reviews the mechanism of Hyaluronidase in malignant tumors, which is expected to provide a new method for early diagnosis, early treatment and prognosis of malignant tumors.
