Clinical outcomes of neoadjuvant chemotherapy with Gemcitabine and Cisplatin for muscle-invasive bladder cancer
10.3760/cma.j.cn115396-20210514-00177
- VernacularTitle:吉西他滨联合顺铂新辅助化疗治疗肌层浸润性膀胱癌的疗效分析
- Author:
Zhipeng WANG
1
;
Sixu WANG
;
Jian ZHANG
;
Jun LIN
;
Yuwen GUO
;
Ye TIAN
;
Yichen ZHU
Author Information
1. 首都医科大学附属北京友谊医院泌尿外科 100050
- Keywords:
Urinary bladder neoplasms;
Antineoplastic combined chemotherapy protocols;
Neoadjuvant chemotherapy;
Gemcitabine;
Cisplatin;
Prognosis
- From:
International Journal of Surgery
2021;48(9):590-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical outcomes of neoadjuvant chemotherapy with Gemcitabine and Cisplatin (GC) for muscle-invasive bladder cancer (MIBC).Methods:Retrospective analysis of 67 MIBC patients admitted to Beijing Friendship Hospital, Capital Medical University from December 2010 to June 2020. Fifty-five MIBC patients (cT2-T4aN0M0) underwent GC plus radical cystectomy-pelvic lymph node dissection. Pathological responses, prognosis and chemotherapy toxicities were analyzed. The Chi-square test and Fisher′s exact probability method were used to compare the count data between groups. The overall survival (OS) and disease-free survival (DFS) were based on the Kaplan-Meier survival curve, and the Log-rank test was used to evaluate the difference between groups in the survival curve. Prognostic analysis adopts Cox proportional hazards regression model.Results:Fifty-five MIBC patients received GC plus radical cystectomy-pelvic lymph node dissection. The 81.8% patients ( n=45) received 2 cycles GC and 18.2% patients ( n=10) received 3 cycles. The complete pathological response (pT0N0M0) rate was 30.9% ( n=17) and partial response (pT 1/Tis/T aN 0M 0) rate was 10.9% ( n=6). Overall pathological response rate was 41.8%. The median follow-up was (47.0±37.7) months, 5-year OS were 82.2% and 22.1% (
