Research of high glucose on the injury of dorsal root ganglion cells
10.3760/cma.j.cn115396-20200203-00020
- VernacularTitle:高糖损伤背根神经节细胞的研究
- Author:
Yadong LIU
1
;
Zhongqing WEI
;
Sicong ZHANG
;
Xiaoming LU
Author Information
1. 盐城市第三人民医院泌尿外科 224000
- Keywords:
Hyperglycemia;
Diabetes mellitus;
Bladder dorsal root ganglion cells;
Mitochondria;
Diabetes complications
- From:
International Journal of Surgery
2021;48(6):410-416
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic bladder dysfunction is one of the most common complications of urinary tract in diabetes. It is believed that the disorders of glucose metabolism, local tissue ischemia, superoxide-induced free radical production and axonal transport disorder are all involved in the development of diabetic bladder nerve dysfunction. Oxidative stress is believed to be the core mechanism of the above mentioned etiology. It may affect the transcription and translation process in the nucleus by interfering with the balance of intracellular oxidation and antioxidant, metabolism of neurotrophic factors and cellular signal transduction pathways, resulting in dysfunction of several important cellular pathways and decreased membrane stability. And eventually lead to nerve cell apoptosis. Therefore, controlling blood glucose, improving the microenvironment around dorsal root neurons, and protecting the stability of mitochondrial membrane may be potential methods for the treatment of diabetic bladder nerve dysfunction.
