Research progress of CCL20-CCR6 axis and epithelial-mesenchymal transition in breast cancer
10.3760/cma.j.cn115396-20210316-00091
- VernacularTitle:CCL20-CCR6轴与上皮-间质转化在乳腺癌中的研究进展
- Author:
Simin YUAN
1
;
Yong YANG
;
Xueying WANG
;
Fenglin CAI
;
Jiaxin ZHANG
Author Information
1. 大连医科大学 116044
- Keywords:
Breast neoplasms;
Tumor microenvironment;
Cytokines CCL20;
Receptors CCR6;
Epithelial-mesenchymal transition
- From:
International Journal of Surgery
2021;48(6):401-405
- CountryChina
- Language:Chinese
-
Abstract:
CCL20 and CCR6 are chemokines produced by a variety of cells. CCL20 and CCR6 combine to stimulate a series of downstream pathways, participate in the occurrence and development of various malignant tumors, and also play an important role in the invasion and metastasis of breast cancer and the process of chemotherapy resistance. Epithelial-mesenchymal transformation (EMT) is a key step in the process of tumor cell metastasis, which is characterized by loss of cell adhesion, down-regulation of E-cherherin expression, up-regulation of mesenchymal markers and fibrinectin expression, and enhancement of cell motor ability and invasion ability. This article reviews the research of CCL20-CCR6 biological axis and EMT on invasion and metastasis of breast cancer cells.
