Research progress of thioredoxin system
10.3760/cma.j.cn121382-20201225-00315
- VernacularTitle:硫氧还蛋白系统研究进展
- Author:
Zihua LIU
1
;
Peng ZHOU
;
Xiaojuan LI
;
Dongrong TANG
;
Wen WANG
;
Yitian REN
;
Jianlin WANG
Author Information
1. 兰州大学生命科学学院动物学与生物医学系 730000
- Keywords:
Thioredoxin;
Thioredoxin reductase;
Thioredoxin interacting protein;
Cancer;
Neurodegenerative disease
- From:
International Journal of Biomedical Engineering
2021;44(3):256-261
- CountryChina
- Language:Chinese
-
Abstract:
The thioredoxin system is composed of thioredoxin (Trx), thioredoxin reductase (TR) and reduced nicotinamide adenine dinucleotide phosphate. Trx is an important antioxidant molecule that can resist cell death caused by various stresses and plays a prominent role in redox reactions. TR is a protein containing selenium (selenocysteine), mainly in three forms, i.e. TR1, TR2 and TR3. TR1 mainly distributed in the cytoplasm, TR2 mainly distributed in the mitochondria, and TR3 mainly distributed in the testes. TR can regulate cell growth and apoptosis. After the cell becomes cancerous, the expression of TR increases to promote cell growth and metastasis. Trx system is closely related to neurodegenerative diseases, parasitic infections, acquired immunodeficiency syndrome, rheumatoid arthritis, hypertension, myocarditis and so on. The Trx system can remove the reactive oxygen species (ROS) in the body, keep the inside and outside of the cell in a balanced state, and it interacts with the thioredoxin interacting protein (TXNIP), which plays an important role in the regulation of glucose metabolism and tumor treatment. The Trx system is an important target for drug treatment of many diseases. In this paper, the research progress of the thioredoxin system was reviewed.
