Research progress in the pathogenesis of alopecia areata
10.3760/cma.j.cn121382-20200910-00214
- VernacularTitle:斑秃发病机制最新研究进展
- Author:
Wenguo WEI
1
;
Sanwu ZENG
Author Information
1. 天津市第一中心医院皮肤科，南开大学医学院，天津 300192
- Keywords:
Alopecia areata;
Pathogenesis;
Genetic;
Autoimmunity
- From:
International Journal of Biomedical Engineering
2021;44(2):168-172
- CountryChina
- Language:Chinese
-
Abstract:
Alopecia areata is a kind of non-scarring hair loss that often occurs in young adults. Alopecia areata often occurs in hairy parts of the body, with normal local skin and no self-conscious symptoms, and is a kind of temporary hair loss. The onset of alopecia areata is usually sudden and unconscious. Therefore, it is also called "ghost shaved head" in Chinese folks. Most ordinary alopecia areata patients can self-heal, but in a few cases alopecia areata will recur and it is difficult to treat. As for the causes of alopecia areata, genetic factors, mental and neurological factors, trace elements, autoimmune factors, etc. can all cause alopecia areata. Alopecia areata looks like a local lesion of the hair, but actually it involves the nervous system, immune system, circulatory system, etc. The etiology of alopecia areata is quite complicated. The possible specific mechanism of alopecia areata is as follows: the hair follicle tissue has ischemia, hypoxia, or immune damage, and then the hair root loses its physiological growth function, and finally the hair falls off. This review paper aims to classify and explain the pathogenesis of alopecia areata in detail, and provide sufficient theoretical basis for clinical treatment of alopecia areata.
