Research progress of mechanism of action of Saccharomyces boulardii and its application in ulcerative colitis
10.3760/cma.j.cn121382-20200917-00213
- VernacularTitle:布拉氏酵母菌的作用机制及其在溃疡性结肠炎中应用的研究进展
- Author:
Ganggang SHI
1
;
Mei HAN
;
Jingpeng HAO
;
Bing ZHENG
Author Information
1. 天津医科大学第二医院肛肠外科 300211
- Keywords:
Saccharomyces boulardii;
Biological characteristics;
Mechanism of action;
Ulcerative colitis;
Intestinal flora
- From:
International Journal of Biomedical Engineering
2021;44(2):163-167
- CountryChina
- Language:Chinese
-
Abstract:
Saccharomyces boulardii is a subspecies of Saccharomyces cerevisiae and is a fungal probiotic. It can regulate the intestinal flora and enhance the barrier function of the intestinal tract. Compared with bacterial probiotics, Saccharomyces boulardii is more resistant to acid and oxidation, does not transmit genetic material with bacteria, and can be used in combination with antibiotics. Saccharomyces boulardii can function through a variety of mechanisms, and many proteases secreted by it have antitoxin effects; its own bacteria contain more polyamines, which can nourish the intestinal mucosal cells and regulate the body's metabolic balance. Besides, it can regulate multiple signal pathways to enhance intestinal immunity. Saccharomyces boulardii has been used in the treatment of ulcerative colitis (UC). The results of animal experiments and clinical studies have shown that the application of Saccharomyces boulardii can improve intestinal inflammation and enhance the therapeutic effect of mesalazine. Saccharomyces boulardii can be used as an auxiliary drug for the treatment of UC.
