Relationship between the level of inflammatory factors and disease state in patients with acute coronary syndrome
10.3760/cma.j.cn121382-20200920-00203
- VernacularTitle:急性冠状动脉综合征患者冠脉内炎性因子水平与患者疾病状态关系
- Author:
Meng NING
1
;
Wenjin PENG
;
Yanhong LIU
;
Hui WANG
;
Guanqun MA
;
Yingwu LIU
Author Information
1. 天津市第三中心医院心脏科 300170
- Keywords:
Acute coronary syndrome;
Inflammatory factors;
Coronary artery diseases;
Clinical events
- From:
International Journal of Biomedical Engineering
2021;44(2):101-105,118
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of infarct vessel diameter, blood flow before operation, blood flow status after operation, coronary artery disease, number of coronary artery lesions and other risk factors on the levels of inflammatory factors IL-1, IL-6, IL-10 in the coronary blood of patients with acute coronary syndrome (ACS), and to determine the relationship between inflammatory factors and ACS and its impact on clinical status.Methods:The peripheral blood and coronary blood of 54 patients with ACS underwent emergency interventional treatment were collected before the operation. The level of IL-1, IL-6, and IL-10 in the blood sample was detected by an automatic biochemical analyzer.Results:Postoperative adverse cardiac events were positively correlated with the patient's age, D-to-B time, and the number of coronary artery lesions (all P<0.05). The levels of IL-1, IL-6 and IL-10 in coronary blood of ACS patients were higher than those in peripheral blood (all P<0.05). The number of coronary artery disease branches (≥3), the onset time of myocardial infarction (>4 h), diabetes mellitus, ischemic post-treatment, preoperative blood flow level ( 2.5 mm, coronary artery disease number ≥ 3, severe right coronary artery disease, preoperative blood flow 22 frames, and cardiovascular events, the IL-10 levels are higher (all P<0.05). Conclusions:The levels of inflammatory factors IL-1, IL-6, and IL-10 in coronary blood of ACS patients are higher than those in peripheral blood, suggesting that acute coronary artery originates from local coronary inflammatory reaction, and the increase of inflammatory factors in peripheral blood belongs to "Erosion" effect. The level of inflammatory factors is significantly related to the diameter of the diseased blood vessel, preoperative blood flow, the number of coronary artery disease, the location of myocardial infarction, diabetes and smoking history.
