Preparation and characterization of hollow copper selenide nanomaterials by sacrificial template method
10.3760/cma.j.cn121382-20201126-00201
- VernacularTitle:牺牲模板法中空硒化铜纳米材料的制备及表征
- Author:
Sinan GUO
1
;
Ruixue RAN
;
Yinsong WANG
Author Information
1. 天津医科大学药学院，天津市临床药物关键技术重点实验室 300070
- Keywords:
Hollow copper selenide nanoparticles;
Sacrificial template method;
Photothermal properties;
Radiosensitization;
Tumor therapy
- From:
International Journal of Biomedical Engineering
2021;44(2):89-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare hollow copper selenide nanoparticles (Cu 2- xSe NPs), and investigate their photothermal properties and radiotherapy sensitization performance. Methods:Hollow copper selenide nanoparticles (Cu 2- xSe NPs) were prepared by sacrificial template method with Cu 2O NPs as sacrificial templates and with selenium powder as selenium source. The surface of copper selenide nanoparticles (Cu 2- xSe NPs) was modified with mercapto-ethylene glycol (mPEG-SH) to obtain Cu 2- xSe-PEG NPs. The morphology, particle size and ultraviolet spectrum of the Cu 2- xSe NPs were characterized by transmission electron microscopy, laser particle size analyzer and ultraviolet spectrophotometer. The photothermal properties and radiosensitization performance of the Cu 2- xSe-PEG NPs were investigated by infrared thermal imager and biological X-ray irradiator. Results:The obtained Cu 2- xSe NPs showed a hollow structure and good monodispersity, and the average diameter were (136.9±7.0) nm. The Cu 2- xSe NPs had absorption in the near-infrared region. When the Cu 2- xSe-PEG NPs sample with the mass concentration of 200 μg/ml were irradiated under 808 nm laser at 1.0 W/cm 2 for 10 min, the temperature raised to more than 55 ℃. The level of reactive oxygen species produced by the Cu 2- xSe-PEG NPs under X-ray irradiation was related to the concentration and radiation dose. Conclusions:The proposed preparation method can control the size of synthesized Cu 2- xSe NPs, and the Cu 2- xSe NPs had good photothermal properties and radiosensitization performance. This work will provide a certain theoretical basis for the application of Cu 2- xSe-PEG NPs in tumor thermoradiotherapy.
