Neurobiological mechanism of post-stroke depression
10.3760/cma.j.issn.1673-4165.2021.10.012
- VernacularTitle:卒中后抑郁的神经生物学机制
- Author:
Yan XING
1
;
Yanmei ZHANG
;
Yating LIU
;
Naizhi ZHENG
Author Information
1. 青岛大学附属青岛市市立医院神经内科 266011
- Keywords:
Stroke;
Depression;
Neurobiology;
Neuroimmunomodulation;
Neuronal plasticity
- From:
International Journal of Cerebrovascular Diseases
2021;29(10):785-788
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke depression (PSD) is one of the common complications of stroke, which can seriously affect the functional rehabilitation of patients with stroke and increase their mortality and disability rate. As for the pathogenesis of PSD, endogenous theory emphasizes that it is closely associated with biological mechanism, while reactive theory believes that it is associated with psychosocial factors. At present, the research on the pathogenesis and treatment of PSD focuses on inflammation, immune response, stress, nerve regeneration, brain network, biological rhythm disorder, sleep disorder, melatonin and so on. This article reviews the research progress on the neurobiological mechanism of PSD and the related treatment for the pathogenesis.
