Endothelin-1 gene Lys198Asn polymorphism and ischemic stroke
10.3760/cma.j.issn.1673-4165.2021.10.010
- VernacularTitle:内皮素-1基因Lys198Asn多态性与缺血性卒中
- Author:
Tingting YU
1
;
Ying LIU
;
Song XU
;
Jianxin JIANG
Author Information
1. 大连医科大学研究生院 116044
- Keywords:
Stroke;
Brain ischemia;
Endothelin-1;
Polymorphism, genetic;
Genetic predisposition to disease
- From:
International Journal of Cerebrovascular Diseases
2021;29(10):776-780
- CountryChina
- Language:Chinese
-
Abstract:
Endothelin (ET) is a potent vasoconstrictor peptide produced by endothelial cells, which is closely associated with vascular endothelial dysfunction and cardio-cerebrovascular diseases. Recent studies have shown that ET-1 gene Lys198Asn polymorphism can be used as a new biomarker of cerebrovascular diseases. This article reviews the research progress on the relationship between the gene polymorphism and susceptibility to ischemic stroke, and discusses its clinical significance.
