Seasonal changes of glycated hemoglobin in patients with acute ischemic stroke in Tianjin
10.3760/cma.j.issn.1673-4165.2021.10.005
- VernacularTitle:天津市急性缺血性卒中患者糖化血红蛋白的季节性变化
- Author:
Miaomiao WEI
1
;
Xiaoshuang XIA
;
Min ZHANG
;
Lin WANG
;
Suqin HAN
;
Xin LI
Author Information
1. 天津医科大学第二医院神经内科，天津 300211
- Keywords:
Stroke;
Brain ischemia;
Glycated hemoglobin A;
Diabetes mellitus;
Seasons
- From:
International Journal of Cerebrovascular Diseases
2021;29(10):744-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the seasonal changes of glycated hemoglobin (HbA1c) in patients with acute ischemic stroke in Tianjin.Methods:Acute ischemic stroke patients with available HbA1c data admitted to the Department of Neurology, the Second Hospital of Tianjin Medical University from January 1, 2011 to December 31, 2020 were enrolled retrospectively. The demographic data, vascular risk factors, baseline clinical data and routine blood test findings were collected. The seasonal changes of various indexes were investigated. Multiple linear stepwise regression analysis was used to determine the influencing factors of HbA1c.Results:A total of 2 721 acute ischemic stroke patients with available HbA1c data were included, of whom 1 779 (65.4%) also had diabetes mellitus, 942 patients (34.6%) did not have diabetes mellitus. The baseline National Institutes of Health Stroke Scale score, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol and uric acid in the winter group were significantly higher than those in the summer group (all P<0.05). HbA1c had seasonal difference in acute ischemic stroke patients without diabetes mellitus ( P<0.05). For acute ischemic stroke patients with diabetes mellitus, HbA1c showed seasonal fluctuations only at HbA1c >7% ( P<0.05). Multiple linear stepwise regression analysis showed that combined with diabetes mellitus, using insulin and/or oral hypoglycemic drugs, fasting blood glucose, uric acid, creatinine and season were the independent infuencing factors of HbA1c. Conclusions:HbA1c in patients with acute ischemic stroke in Tianjin is characterized by seasonal fluctuations, which is high in winter and spring and low in summer and autumn. This difference is related to the level of HbA1c.
