Targeted ion channel therapy for acute ischemic stroke and cerebral edema
10.3760/cma.j.issn.1673-4165.2021.09.011
- VernacularTitle:急性缺血性卒中脑水肿靶向离子通道治疗
- Author:
Wenmin YIN
1
;
Luqing ZHAO
;
Weili LIN
Author Information
1. 山西医科大学第五临床医学院神经内科，太原 030001
- Keywords:
Stroke;
Brain ischemia;
Brain edema;
Blood-brain barrier;
Ion channels
- From:
International Journal of Cerebrovascular Diseases
2021;29(9):698-702
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral edema and its caused elevated intracranial pressure are one of the main causes of death in patients with acute ischemic stroke. The main pathogeneses of brain edema include cytotoxic edema, ionic edema, and angiogenic edema. At present, the treatment strategies used to control brain edema and reduce intracranial pressure are mainly osmotic drugs and hemicraniectomy decompression, which are symptomatic treatments to reduce intracranial pressure. In recent years, it has been proposed to inhibit the ion channel in the formation of brain edema as a therapeutic target, which provides a new direction for the treatment of brain edema.
