Interleukin-18 and post-stroke depression
10.3760/cma.j.issn.1673-4165.2021.09.010
- VernacularTitle:白细胞介素-18与卒中后抑郁
- Author:
Huihui QIU
1
;
Rong YIN
Author Information
1. 甘肃中医药大学第一临床医学院研究生院，兰州 730000
- Keywords:
Stroke;
Depression;
Interleukin-18;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2021;29(9):693-697
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke depression (PSD) can seriously affect the outcome and quality of life of patients with stroke. However, due to the lower diagnostic rate, a large number of patients with PSD have not been treated in time and have a poor outcome. Therefore, only early detection, early diagnosis and early treatment of PSD can improve the prognosis and quality of life of patients with stroke. In recent years, a large number of studies on serum biomarkers have tried to find objective indicators related to PSD. Among them, interleukin-18 is associated with the pathogenesis of stroke and PSD, which may be attributed to its polymorphism and constitutive expression in the brain, especially the role of serum level changes in the risk stratification and outcome of acute ischemic stroke. This article reviews the role of interleukin-18 in the pathogenesis of PSD.
