Correlation between metabolic syndrome and early neurological deterioration in patients with minor stroke or high-risk transient ischemic attack
10.3760/cma.j.issn.1673-4165.2021.09.005
- VernacularTitle:代谢综合征与轻型卒中或高危短暂性脑缺血发作患者早期神经功能恶化的相关性
- Author:
Zuowei DUAN
1
;
Haiyan LIU
;
Jiang XU
;
Junjun SHAN
;
Xiu'e WEI
Author Information
1. 徐州医科大学第二附属医院神经内科 221006
- Keywords:
Stroke;
Ischemic attack, transient;
Metabolic syndrome;
Severity of illness index;
Disease progression;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2021;29(9):666-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between metabolic syndrome (MetS) and early neurological deterioration (END) in patients with acute minor ischemic stroke (MIS) and high-risk transient ischemic attack (TIA).Methods:Consecutive patients with acute MIS or high-risk TIA admitted to the Second Affiliated Hospital of Xuzhou Medical University between May 2018 and June 2020 were enrolled prospectively. MIS was defined as the National Institutes of Health Stroke Scale (NIHSS) score ≤3, high-risk TIA was defined as ABCD 2 score ≥4, and END was defined as the highest score of NIHSS within 72 h after admission increased by ≥1 compared with the baseline. Multivariate logistic regression analysis was used to determine the correlation between MetS or its component and END. Results:A total of 145 patients with acute MIS or high-risk TIA were enrolled, including 66 males (45.5%), aged 68.28±9.71 years. Fifty-two patients (35.9%) met the diagnostic criteria of MetS, and 46 (31.7%) developed END. Univariate analysis showed that there were significant differences in age, sex, atrial fibrillation, elevated blood glucose, MetS, fasting blood glucose and C-reactive protein between the END group and the non-END group (all P<0.05). Multivariate logistic regression analysis showed that MetS (odds ratio 2.637, 95% confidence interval 1.127-6.169) and high blood glucose (odds ratio 2.672, 95% confidence interval 1.052-6.789) were the independent risk factors for END within 72 h of admission in patients with acute MIS or high-risk TIA. Conclusion:MetS is significantly associated with END in patients with acute MIS or high-risk TIA.
