Effect of renal insufficiency on the treatment of patients with ischemic stroke
10.3760/cma.j.issn.1673-4165.2021.08.009
- VernacularTitle:肾功能不全对缺血性卒中患者治疗的影响
- Author:
Xin SUN
1
;
Ruibing GUO
Author Information
1. 南京大学医学院附属金陵医院（东部战区总医院）神经内科，南京 210002
- Keywords:
Stroke;
Brain ischemia;
Renal insufficiency, chronic;
Platelet aggregation inhibitors;
Anticoagulants;
Thrombolytic therapy;
Endovascular procedures;
Thrombe
- From:
International Journal of Cerebrovascular Diseases
2021;29(8):608-612
- CountryChina
- Language:Chinese
-
Abstract:
Patients with chronic kidney dysfunction (CKD) have abnormal coagulation function and impaired drug metabolism, resulting in increased bleeding risk and decreased drug clearance. Therefore, while receiving treatment, the prognosis of ischemic stroke patients with CKD is different from that of ischemic stroke patients without CKD. For patients with CKD who need anticoagulant treatment, the use of new anticoagulants without renal metabolism can achieve the same anticoagulant effect as warfarin, and the risk of bleeding is lower. When using antiplatelet drugs, due to the increased risk of bleeding in ischemic stroke patients with CKD, the clinical benefits and bleeding risk should be carefully weighed. Although CKD is not an absolute contraindication of intravenous thrombolysis or endovascular treatment in patients with acute ischemic stroke, attention should be paid to the influence of CKD on the increased risk of death in patients with ischemic stroke after treatment.
