Role and mechanism of mixed lineage kinase domain-like protein in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2021.07.012
- VernacularTitle:混合谱系激酶结构域样蛋白在脑缺血中的作用及其机制
- Author:
Xiaomei LU
1
;
Lixuan ZHAN
;
Wensheng XU
;
En XU
Author Information
1. 广州医科大学神经科学研究所，广州医科大学附属第二医院神经内科，广州 510260
- Keywords:
Brain ischemia;
Protein kinases;
Protein multimerization;
Cell death;
Necroptosis;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2021;29(7):544-548
- CountryChina
- Language:Chinese
-
Abstract:
Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase with a kinase domain, which plays an important role in the regulation of necroptosis. After cerebral ischemia, MLKL, as the substrate protein of the receptor-interacting protein 3, undergoes oligomerization and phosphorylation, and then translocates from the cytoplasm to the plasmalemma, causing mitochondrial division and cell membrane rupture. MLKL can also mediate the inflammatory response after cerebral ischemia by inducing necroptosis and directly activating inflammasomes, thereby aggravating brain injury. Therefore, to clarify the biological characteristics of MLKL and its role and mechanism in cerebral ischemia is very important for the treatment of cerebral ischemia.
