Diabetes mellitus and post-stroke cognitive impairment
10.3760/cma.j.issn.1673-4165.2021.07.009
- VernacularTitle:糖尿病与卒中后认知损害
- Author:
Mengjia YANG
1
;
Mingsi ZHANG
;
Chuhong TAN
;
Genghong XIA
;
Jia YIN
Author Information
1. 南方医科大学南方医院神经内科，广州 510515
- Keywords:
Stroke;
Brain ischemia;
Cognition disorders;
Cognition;
Diabetes mellitus
- From:
International Journal of Cerebrovascular Diseases
2021;29(7):526-531
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes can significantly increase the risk of post-stroke cognitive impairment (PSCI). Previous studies have shown that diabetes can be involved in the occurrence of cognitive impairment by insulin resistance, blood-brain barrier damage, low level inflammation, β-amyloid deposition and tau phosphorylation, aggravation of ischemic brain injury and oxidative stress. In recent years, the role of diabetes in the pathophysiology of PSCI is attracting increasing attention. This article reviews the correlation between diabetes mellitus and PSCI and the possible pathophysiological mechanisms, hoping to provide reference for prevention and treatment strategies of PSCI in diabetics.
