Mechanism of microglia involved in the pathophysiology of brain white matter hyperintensity
10.3760/cma.j.issn.1673-4165.2021.06.013
- VernacularTitle:小胶质细胞参与脑白质高信号病理生理学的机制
- Author:
Hongyi YU
1
;
Zhongyi JIA
;
Zhongling ZHANG
Author Information
1. 哈尔滨医科大学附属第一医院神经内科，哈尔滨 150001
- Keywords:
White matter;
Cerebrovascular disorders;
Microglia;
Blood-brain barrier;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2021;29(6):467-470
- CountryChina
- Language:Chinese
-
Abstract:
As an important imaging marker of cerebral small vessel disease, white matter hyperintensity is closely associated with the clinical manifestations such as cognitive impairment, gait abnormalities, and urinary incontinence. Current studies have shown that the destruction of blood-brain barrier and inflammation response are the important pathophysiological mechanisms of white matter hyperintensity. As the most common immune cell in the inflammatory response of the central nervous system, microglia activation is the key to the occurrence and development of white matter hyperintensity. This article reviews the pathophysiological mechanisms of microglia involved in brain white matter hyperintensity.
