Role of pericytes in the pathogenesis of cerebral small vessel disease
10.3760/cma.j.issn.1673-4165.2021.06.012
- VernacularTitle:周细胞在脑小血管病发病机制中的作用
- Author:
Haihong NIE
1
;
Xiaoxue CHEN
;
Zhongling ZHANG
Author Information
1. 哈尔滨医科大学附属第一医院神经内科，哈尔滨 150001
- Keywords:
Cerebral small vessel diseases;
Pericytes;
Inflammation;
Blood-brain barrier
- From:
International Journal of Cerebrovascular Diseases
2021;29(6):463-466
- CountryChina
- Language:Chinese
-
Abstract:
Pericytes are located between capillary endothelial cells, astrocytes and neurons. They have many functions such as maintaining the integrity of blood-brain barrier and regulating cerebral blood flow. Loss of pericytes can lead to pathological processes such as brain microcirculation dysfunction and blood-brain barrier destruction, and is associated with a variety of diseases, but there are few studies on the correlation between them and cerebral small vessel disease. This article mainly reviews the role of pericytes in the pathogenesis of cerebral small vessel disease.
