Correlation between MTHFR gene C677T polymorphism, homocysteine and early neurological deterioration in Han population with acute ischemic stroke in Chengdu area
10.3760/cma.j.issn.1673-4165.2021.06.004
- VernacularTitle:MTHFR基因C677T多态性、高半胱氨酸与成都地区汉族人群急性缺血性卒中患者早期神经功能恶化的相关性
- Author:
Qiang ZHOU
1
;
Yan HUANG
;
Hui TANG
;
Li DENG
;
Haitao ZHANG
;
Li GAO
;
Hua LIU
Author Information
1. 成都市第三人民医院，西南交通大学附属医院神经内科 610031
- Keywords:
Stroke;
Brain ischemia;
Disease progression;
Methylenetetrahydrofolate reductase (NADPH2);
Polymorphism, genetic;
Homocysteine;
Hyperhomocysteinemia;
Risk fa
- From:
International Journal of Cerebrovascular Diseases
2021;29(6):420-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and early neurological deterioration (END) in Han population with acute ischemic stroke in Chengdu area, and the interaction with other traditional risk factors.Methods:Consecutive Han patients with acute ischemic stroke admitted to the Department of Neurology, the Third People's Hospital of Chengdu from January 2017 to June 2019 were enrolled prospectively. Using the candidate gene association study method, MTHFR gene C677T polymorphism was used as a genetic marker to analyze the correlation between END and MTHFR gene polymorphism, and analyze the interaction of gene-END traditional risk factors.Results:A total of 434 patients with acute ischemic stroke were enrolled in the study, and 129 had END (29.7%). Multivariate logistic regression analysis showed that hyperglycemia (odds ratio [ OR] 2.410, 95% confidence interval [ CI] 1.436-4.046; P<0.001), hyperhomocysteinemia ( OR 2.570, 95% CI 1.229-5.376; P=0.012) and moderate to severe neurological deficit (baseline National Institutes of Health Stroke Scale score >5) ( OR 2.158, 95% CI 1.337-3.484; P=0.002) at admission were independently correlated with END. There was a correlation between C677T polymorphism and END. TT genotype ( OR 1.710, 95% CI 1.021-2.863; P=0.002) and A allele ( OR 1.583, 95% CI 1.181-2.121; P=0.002) could significantly increase the risk of END. Interaction analysis showed that there was interaction effect between C677T polymorphism and hyperglycemia at admission, alcohol drinking and moderate to severe neurological deficit. Interaction could increase the risk of END, but it did not reach statistical significance ( OR 1.237, 95% CI 0.227-6.734; P=0.806). Conclusion:MTHFR gene C677T polymorphism and hyperhomocysteinemia are associated with END in Han population with acute ischemic stroke in Chengdu area.
