Hyperhomocysteinemia is a risk factor for intracranial aneurysms
10.3760/cma.j.issn.1673-4165.2021.05.006
- VernacularTitle:高同型半胱氨酸血症是颅内动脉瘤的危险因素
- Author:
Maimaitiaili KUERBAN
1
;
Kuerban AJIMU
Author Information
1. 喀什地区第一人民医院神经外科 844000
- Keywords:
Intracranial aneurysm;
Hyperhomocysteinemia;
Homocysteine;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2021;29(5):347-350
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between hyperhomocysteinemia (HHcy) and the onset of intracranial aneurysm (IAs).Methods:Patients with IA visited the Department of Neurosurgery, the First People's Hospital of Kashgar from February 2017 to November 2020 were retrospectively included as a case group, while patients with trigeminal neuralgia visited the hospital at the same time were selected as a control group. Demographic data, vascular risk factors and laboratory findings were compared between the two groups. Multivariate logistic regression analysis was used to determine the correlation between HHcy and IAs. Results:A total of 150 patients with IA (case group) and 112 patients with trigeminal neuralgia (control group) were included. Univariate analysis showed that there were significant differences in age, hypertension, drinking, triglyceride, low-density lipoprotein cholesterol, total Hcy and HHcy between the two groups (all P<0.05). Multivariate logistic regression analysis showed that there were significant independent correlation among males (odds ratio [ OR] 0.320, 95% confidence interval [ CI] 0.167-0.613; P=0.001), hypertension ( OR 4.915, 95% CI 2.674-9.036; P<0.001), triglycerides ( OR 1.342, 95% CI 1.030-1.750; P=0.030), total Hcy ( OR 1.171, 95% CI 1.082-1.268; P<0.001), HHcy ( OR 3.574, 95% CI 1.522-8.391; P=0.003) and IAs. Conclusion:HHcy is an independent risk factor for the increased risk of IAs.
