Risk factors and early neurological deterioration in proximal single subcortical infarction: comparison with distal single subcortical infarction
10.3760/cma.j.issn.1673-4165.2021.05.001
- VernacularTitle:近端单发性皮质下梗死的危险因素和早期神经功能恶化：与远端单发性皮质下梗死的比较
- Author:
Yinyan WU
1
;
Kun ZHAO
;
Xuezhong LI
;
Xiaopeng CHEN
Author Information
1. 江苏大学附属人民医院神经内科，镇江 212001
- Keywords:
Infarction, middle cerebral artery;
Magnetic resonance imaging;
Magnetic resonance angiography;
Disease progression;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2021;29(5):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors for different types of single subcortical infarction (SSI) in middle cerebral artery territory and the risk factors for early neurologic deterioration (END).Methods:Patients with SSI in middle cerebral artery territory admitted to the Department of Neurology, People's Hospital Affiliated to Jiangsu University from January 2020 to April 2021 were enrolled retrospectively. According to the distribution of infarction, the patients were divided into proximal SSI (pSSI) and distal SSI (dSSI). The demographics, vascular risk factors and baseline clinical data were collected. END was defined as new signs and/or symptoms of neurological deficit or aggravation of any neurological deficit within 2 weeks after onset. Multivariate logistic regression analysis was used to determine the independent risk factors for pSSI and END. Results:Seventy-six patients with acute SSI in the middle cerebral artery territory were included, 41 patients (53.9%) in the pSSI group, 35 (46.1%) in the dSSI group; 13 (17.1%) in the END group, and 63 (82.9%) in the non-END group. There were no significant differences in age, gender, vascular risk factors and baseline National Institutes of Health Stroke Scale score between the pSSI group and the dSSI group. The total cholesterol, fasting blood glucose levels and the ratio of pSSI in the END group were significantly higher than those in the non-END group ( P<0.05), while the high-density lipoprotein cholesterol level was significantly lower than that of the non-END group ( P<0.05). Multivariate logistic regression analysis showed that pSSI was an independent risk factor for the occurrence of END in patients with SSI (odds ratio 6.75, 95% confidence interval 1.26-36.23; P=0.026). Conclusion:There was no significant difference in risk factors between pSSI and dSSI, but patients with pSSI were more prone to END.
