Advance in the relationship between gut microbiota and GH-IGF-1 axis
10.3760/cma.j.issn.1673-4408.2021.11.005
- VernacularTitle:肠道菌群与GH-IGF-1轴相关性研究进展
- Author:
Jing MIAO
1
;
Yunguang BAO
;
Mizu JIANG
Author Information
1. 浙江大学医学院附属儿童医院 国家儿童健康与疾病临床医学研究中心 国家儿童区域医疗中心，杭州 310052
- Keywords:
Intestinal flora;
Growth hormone;
Insulin-like growth factor;
Growth and development
- From:
International Journal of Pediatrics
2021;48(11):741-744
- CountryChina
- Language:Chinese
-
Abstract:
Nowadays, more and more attention was attached to the problem of children′s growth and development.It is known that postnatal growth is mainly regulated by the conserved GH-IGF-1 axis that acts through endocrine and paracrine pathways.It is now well established that undernourished children harbor an altered microbiota, correlated with impaired growth.Moreover, many disorders of intestinal flora are always accompanied by growth retardation.These evidences show that there might be a certain relationship between intestinal flora and growth and development.Recent studies have demonstrated that intestinal flora may regulate the growth and development process through this axis, and GH-IGF-1 axis may also affect the composition and diversity of intestinal flora.This paper reviewes the bidirectional regulatory relationship between intestinal microbiota and the GH-IGF-1 axis to reveal the functional relationship between growth and development of children and GH-IGF-1 axis as well as the intestinal flora.By elucidating the influence of intestinal flora on growth and development, a new approach would be found for the application of therapeutic methods of microflora in the field of growth retardation in children.
