E - cadherin Expression in Carcinoma of The Uterine Cervix.
- Author:
Kie Suk OH
;
Hee Jae JOO
;
Sun Young KIM
;
Hee Sug RYU
;
Tae Young CHUNG
;
Ki Hong CHANG
- Publication Type:Original Article
- Keywords:
Adhesion molecule;
E-cadherin;
Cervical cancer;
Invasion;
Metastasis
- MeSH:
Cadherins;
Carcinoma in Situ;
Cervix Uteri*;
Cytoplasm;
Epithelium;
Female;
Immunohistochemistry;
Lymph Nodes;
Neoplasm Metastasis;
Uterine Cervical Neoplasms
- From:Korean Journal of Obstetrics and Gynecology
1999;42(2):333-338
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of the present study was to evaluate the E-cadherin expression in normal cervical epithelium, carcinoma in situ of the cervix, and invasive carcinoma of the cervix, and to define the role of E-cadlherin expression in tumor invasion with respect to clinicopathologic parameters. METHODS: We conducted immunodetection of E-cadherin in 58 cases of cervical carcinoma using immunohistochemistry in formalin-fixed, paraffin-embbeded sections, RUSULTS: E-cadherin expression was different between normal cervical epithelium and carcinoma in situ of the cervix, and between normal cervical epithelium and invasive carcinoma of the cervix(p<0.05). However, there was no difference in E-cadherin expression between carcinoma in situ and invasive carcinoma of the cervix. In invasive cervical carcinomas, expression of E-cadherin and the intensity of cytoplasmic E-cadherin expression did not correlate with histologic type, lymphvascular space invasion, lymph node metastasis, and stage of disease. CONCLUSION: It is mncluded that expression of E-cadherin is related to tumor invasion in cervical tissues, but further studies with regard toE-cadherin/catenin/cytoskeleton complex are needed to clarify the prognostic role of E-cadherin with respect to clinicopathologic parameters in invasive cervical carcinoma,
