Progress in the mechanism of estrogen receptors in skeletal muscle diseases
10.3760/cma.j.issn.1673-4408.2021.08.012
- VernacularTitle:雌激素受体在骨骼肌疾病中的机制研究进展
- Author:
Sijia LI
1
;
Shusheng FAN
;
Xiaofei HHUANG
;
Chunjie LI
;
Zhenzhou JIANG
Author Information
1. 中国药科大学新药筛选中心，南京 210009
- Keywords:
Estrogen receptor;
Duchenne Muscular Dystrophy;
Myotubular myopathy;
Estrogen
- From:
International Journal of Pediatrics
2021;48(8):555-558
- CountryChina
- Language:Chinese
-
Abstract:
Estrogen receptors are steroid receptors, widely distributed in skeletal muscle, liver and other tissues.Currently, there are 5 known estrogen receptors.Different estrogen receptors are distributed in different places and have different functions.By mediating different estrogen receptors, estrogen plays an important role in anti-inflammation, promoting proliferation and inhibiting muscle atrophy.Skeletal muscle is the main tissue in the human body, accounting for about 40% of body weight.Skeletal muscle not only plays the role of exercise and support, but also plays an important role in maintaining the body′s metabolism.In recent years, estrogen receptors have received extensive attention in skeletal muscle diseases.Estrogen receptors are considered as potential targets for the treatment of skeletal muscle diseases such as Duchenne muscular dystrophy(DMD)and myotubular myopathy(MTM). This article reviews the research progress of estrogen receptors in skeletal muscle diseases.
