Progress in Kawasaki disease complicated with macrophage activation syndrome
10.3760/cma.j.issn.1673-4408.2021.08.005
- VernacularTitle:川崎病合并巨噬细胞活化综合征研究进展
- Author:
Yuanyuan LI
1
;
Biquan CHEN
Author Information
1. 安徽省儿童医院感染科，合肥 230051
- Keywords:
Kawasaki disease;
Macrophage activation syndrome;
Pathogenesis;
Clinical characteristics;
Diagnosis;
Treatment
- From:
International Journal of Pediatrics
2021;48(8):525-528
- CountryChina
- Language:Chinese
-
Abstract:
Macrophage activation syndrome(MAS)is a rare and fatal complication of Kawasaki disease.So far, many possible causative factors have been explored, including infectious agents and immunologic mechanisms, but the exact etiology remains unclear.Early diagnosis and timely and reasonable treatment are needed for it, because of its insidious onset, rapid progression, multiple organ system involvement, critical clinical symptoms and high mortality.There is no international unified diagnostic criteria and treatment regimen for Kawasaki disease complicated with macrophage activation syndrome at present, many children have the missed diagnosis and miss the best time for treatment.This review aims to analyze Kawasaki disease complicated with macrophage activation syndrome in detail in terms of epidemiology, pathogenesis, clinical characteristics, diagnosis and treatment in order to establish the more specific diagnostic criteria and the more standardized treatment to enable children with such severe KD to receive timely diagnosis and appropriate treatment.
