Progress in the pathogenesis of congenital bicuspid aortic valves and the associated complications

VernacularTitle:先天性二叶式主动脉瓣及其相关并发症的发病机制研究进展
Author: Huan HU ¹ ; Yuejuan XU ; Sun CHEN ; Kun SUN
Author Information

1. 上海交通大学医学院附属新华医院小儿心脏中心　200092
Keywords: Bicuspid aortic valves; Congenital heart disease; Pathogenesis
From: International Journal of Pediatrics 2021;48(8):507-510
CountryChina
Language:Chinese
Abstract: Congenital bicuspid aortic valves(BAV)is one of the most common congenital heart diseases.It is generally diagnosed by echocardiography when deterioration of the abnormal leaflets becomes clinically evident.Patients with BAV are at increased risks of developing serious complications, including aortic stenosis, aortic regurgitation, aortic dilation, aortic dissection and/or aneurysm, which seriously threatens the health of patients.Although its diagnosis and surgical treatment have been clear, the specific pathogenesis has not been completely revealed.Recently, studies have found that gene mutations and related signaling pathway abnormalities are associated with BAV and its complications.And epigenetics and environmental factors are involved in the development and progress of BAV.Understanding the underlying cellular and molecular basis of normal and pathological aortic valve development may improve the preventative and therapeutic approaches to valve degeneration.