Progress on the mechanism and intervention of glutamate AMPA receptor GluA2/TARPγ-8 in the pathogenesis of epilepsy
10.3760/cma.j.issn.1673-4408.2021.07.005
- VernacularTitle:谷氨酸AMPA受体GluA2/TARPγ-8在癫痫发病中的机制及其干预研究进展
- Author:
Menglu WANG
1
;
Jiwen WANG
Author Information
1. 上海交通大学附属上海儿童医学中心神经内科 200127
- Keywords:
Epilepsy;
AMPA receptor;
TARPs;
GluA2/TARPγ-8 complex
- From:
International Journal of Pediatrics
2021;48(7):455-458
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy occurs as a result of episodic abnormal synchronous discharges in cerebral neuronal networks.It is characterized by an imbalance between excitatory and inhibitory neurotransmission.Although various non-conventional mechanisms are implicated in epileptic synchronization, glutamate excitatory neurons play an essential role.AMPA receptors mediate fast synaptic excitation within and between brain regions relevant to epilepsy, and play a role in epileptogenesis and in seizure-induced brain damage.However, direct modulation of AMPA receptors may have undesirable consequences, given its wide expression within the central nervous system and critical roles on brain circuitry development.Hippocampal CA1 region, as the main site of epilepsy, selectively regulates the high expression of AMPA receptor GluA2 subunit and transmembrane AMPA receptor regulatory protein family(TARPs)γ-8 subtype and its complex GluA2/TARPγ-8, whether it can produce anti-epileptic and avoid adverse reactions.
