The hereditary characteristics and promising therapeutic targets of neuroblastoma
10.3760/cma.j.issn.1673-4408.2021.06.009
- VernacularTitle:神经母细胞瘤中的遗传改变及潜在的药物靶点
- Author:
Siqi WANG
1
;
Yijin GAO
Author Information
1. 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 200127
- Keywords:
Children;
Neuroblastoma;
Mutation;
Targeted-therapy
- From:
International Journal of Pediatrics
2021;48(6):401-404
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma(NB)has the highest incidence in pediatric extracranial solid tumors, so its pathogenesis is urgently needed to figure out and guide the targeted therapies.Both heterogeneous pathological characteristics and various clinical phenotypes show that NB has cryptic biological and genetic features.This paper reviews the evidence of gene mutations and epigenetic changes in NB to prospect for new therapeutic targets.
