Relationship between airway epithelial barrier dysfunction and allergic asthma
10.3760/cma.j.issn.1673-4408.2021.06.004
- VernacularTitle:呼吸道上皮屏障功能障碍与过敏性哮喘的关系
- Author:
Qian ZHAO
1
;
Man TIAN
Author Information
1. 南京医科大学附属儿童医院呼吸科 210008
- Keywords:
Inhaled allergen;
Allergic asthma;
Airway epithelial barrier dysfunction;
Epigenetic modification
- From:
International Journal of Pediatrics
2021;48(6):377-380
- CountryChina
- Language:Chinese
-
Abstract:
Airway epithelial barrier dysfunction has been observed in allergic asthma patients.Inhaled allergens have shown a disruptive effect on the airway epithelial barrier.Airway barrier related genetic variation and epigenetics are also involved in the airway epithelial barrier dysfunction.A lot of studies believe that airway epithelial barrier dysfunction underlie the development of asthma.The study of the relationship between allergic asthma and airway epithelial barrier function will be helpful to understand the pathogenesis of allergic asthma and provide new ideas for the treatment of allergic asthma.
