Angioimmunoblastic T-cell lymphoma complicated with Epstein-Barr virus-positive diffuse large B-cell lymphoma: report of two cases and review of literature
10.3760/cma.j.cn115356-20210201-00031
- VernacularTitle:血管免疫母细胞性T细胞淋巴瘤并发EB病毒阳性弥漫大B细胞淋巴瘤二例并文献复习
- Author:
Junli CHEN
1
;
Yun SHAO
;
Xilin CHEN
Author Information
1. 解放军总医院第五医学中心血液病医学部，北京 100071
- Keywords:
Lymphoma, large B-cell, diffuse;
Composite lymphoma;
Discordant lymphoma;
Angioimmunoblastic T-cell lymphoma;
Epstein-Barr virus infections
- From:
Journal of Leukemia & Lymphoma
2021;30(10):609-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features, treatment and prognosis of patients with angioimmunoblastic T-cell lymphoma (AILT) complicated with Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL).Methods:The clinical data of 2 cases of AILT with EBV-positive DLBCL in the Fifth Medical Center of PLA General Hospital were retrospectively analyzed, and the literature was reviewed.Results:One case of complex lymphoma (CL) developed from low fever with systemic superficial lymphadenopathy, the right axillary tumor biopsy showed that AILT complicated with EBV-positive DLBCL. After 8 cycles of chemotherapy, the patient reached unconfirmed complete remission, then received maintenance treatment with chidamide and survived until the deadline. Another case of discordant lymphoma began with subcutaneous nodules and then developed progressive enlargement of superficial lymph nodes. The pathological examination of subcutaneous nodule diagnosed as DLBCL, and the pathological examination of right inguinal lymph node diagnosed as AITL. After 7 cycles of chemotherapy, the patient died of hemophagocytic syndrome.Conclusions:AILT with EBV-positive DLBCL is rare. The main clinical symptom is AITL and the immunophenotypic characteristic indicates the presence of T cells and B cells. At the same time, the prognosis is poor, and the treatment strategy mainly depends on the lymphoma type with unfavorable prognosis.
