Clinical prognosis of lymphoma-associated hemophagocytic syndrome in adults: a multicenter study
10.3760/cma.j.cn115356-20210330-00062
- VernacularTitle:成年人淋巴瘤相关噬血细胞综合征临床预后多中心研究
- Author:
Ziyuan SHEN
1
;
Chenlu HE
;
Ying WANG
;
Qinhua LIU
;
Hao ZHANG
;
Yuqing MIAO
;
Weiying GU
;
Chunling WANG
;
Ling WANG
;
Jingjing YE
;
Yingliang JIN
;
Wei SANG
;
Taigang ZHU
Author Information
1. 徐州医科大学公共卫生学院流行病与卫生统计学系，江苏 徐州 221004
- Keywords:
Lymphohistiocytosis, hemophagocytic;
Lymphoma;
Adult;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2021;30(9):542-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prognostic influencing factors of adult lymphoma-associated hemophagocytic syndrome (LAHS) based on multicenter data.Methods:The clinical data of 86 LAHS patients diagnosed in 9 medical centers of Huaihai Lymphoma Working Group from January 2015 to August 2020 were retrospectively analyzed. The optimal cut-off value of continuous variables was obtained based on MaxStat algorithm. Cox proportional hazard regression model was used for univariate and multivariate analyses. Kaplan-Meier method was used for survival analysis, and log-rank test was performed.Results:Among the 86 adult LAHS patients, 50 (58.1%) were males and 36 (41.9%) were females, the median age of the patients was 57 years old (19-76 years old), and the median overall survival (OS) time was 1.67 months (95% CI 0.09- 3.24 months). The most common pathologic type was diffuse large B-cell lymphoma (58 cases, 67.44%). Based on MaxStat algorithm, the optimal cut-off values of age, albumin, serum creatinine, lactate dehydrogenase, fibrinogen and platelet count were 64 years old, 30.1 g/L, 67 μmol/L, 1 045 U/L, 4.58 g/L and 72×10 9/L, respectively. Multivariate analysis showed that patient's age, lactate dehydrogenase, albumin and fibrinogen levels were independent influencing factors for OS (all P < 0.05). Conclusions:LAHS is dangerous and progresses quickly. Patients with age ≥ 64 years old, lactate dehydrogenase ≥ 1 045 U/L, fibrinogen ≥ 4.58 g/L and albumin < 30.1 g/L have poor survival.
