Progress of the mechanism of Wnt signaling pathway in T-cell acute lymphoblastic leukemia

VernacularTitle:Wnt信号通路在急性T淋巴细胞白血病中作用机制的研究进展
Author: Yiyao LI ¹ ; Min SHI ; Peiying KANG ; Yongjun LI
Author Information

1. 河北医科大学第二医院检验科，石家庄　050000
Keywords: Precursor T-cell lymphoblastic leukemia-lymphoma; Wnt signaling pathway; Hematopoietic stem cells; T-lymphocytes
From: Journal of Leukemia & Lymphoma 2021;30(8):505-508
CountryChina
Language:Chinese
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is derived from the malignant transformation and clonal proliferation of precursor T cells. T-ALL is usually associated with the genetic mutations and/or chromosomal translocation, thus causing the change of survival, proliferation and progenitor cell differentiation of T cells in T-cell development. Studies have shown that Wnt signaling pathway plays a key role in the regulation of hematopoietic stem cell and normal T-cell development, and it is also abnormally altered in T-ALL. This article reviews the research progress of the mechanism of Wnt signaling pathway in T-ALL development.