Expressions of cyclin D2 and bcl-2 in diffuse large B-cell lymphoma and their clinical significances
10.3760/cma.j.cn115356-20201112-00272
- VernacularTitle:cyclin D2和bcl-2在弥漫大B细胞淋巴瘤中的表达及其临床意义
- Author:
Qiushuang MA
1
;
Ling LI
;
Yafei ZHAO
;
Jirui SUN
;
Bingjuan ZHOU
;
Huijuan GENG
;
Jinku ZHANG
Author Information
1. 河北省保定市第一中心医院病理科 071000
- Keywords:
Lymphoma, large B-cell, diffuse;
Cyclin D2;
Genes, bcl-2
- From:
Journal of Leukemia & Lymphoma
2021;30(7):407-410
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions and significance of cyclin D2 and bcl-2 in diffuse large B-cell lymphoma (DLBCL) and their clinical significances.Methods:The tissues of 87 DLBCL patients undergoing resection and 23 patients with lymphoid tissue reactive hyperplasia (RLH) in the First Central Hospital of Baoding from January 2015 to March 2020 were collected. Immunohistochemistry method was used to detect the expressions of cyclin D2 and bcl-2 in tissues of DLBCL and RLH, and the relationship between the expressions of cyclin D2 and bcl-2 as well as the association with the clinicopathological features of DLBCL patients.Results:The positive rates of cyclin D2 protein in DLBCL and RLH were 33.3% (29/87) and 2.0% (1/23), the positive rates of bcl-2 protein in DLBCL and RLH were 60.9% (54/87) and 7.0% (3/23); the positive rates of cyclin D2 and bcl-2 in DLBCL were higher than those in RLH, and the differences were statistically significant( χ2=7.566, P=0.006; χ2=17.512, P < 0.01). The expressions of cyclin D2 and bcl-2 proteins were related to the Ann Arbor staging and immunophenotype of DLBCL patients (all P < 0.05), while not related to age, gender, cancer location, tissue type (all P > 0.05). There was a positive correlation between the expressions of cyclin D2 and bcl-2 protein in DLBCL ( r=1.000, P < 0.01). Conclusions:cyclin D2 and bcl-2 may be related to the development and progression of DLBCL, and both may have some synergies.
