The effects of Shexiang Baoxin pills combined with intracoronary injection of nicorandil on myocardial blood perfusion and short-term prognosis for STEMI patients after PPCI
10.12206/j.issn.1006-0111.202008009
- VernacularTitle:麝香保心丸联合冠脉内注射尼可地尔对STEMI患者PPCI术后心肌血流灌注及近期预后的影响
- Author:
Jingjing HUANG
1
;
Hao CHEN
2
;
Linrui LI
2
;
Zhurong LUO
2
;
Xianliang LIN
2
Author Information
1. The Third People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China.
2. No. 900 Hospital of Joint Logistics Support Force of the PLA, Fuzhou 350000, China.
- Keywords:
Shexiang Baoxin pills;
nicorandil;
STEMI;
corrected TIMI frame count
- From:
Journal of Pharmaceutical Practice
2022;40(1):79-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Shexiang Baoxin pill combined with intracoronary injection of nicorandil on myocardial perfusion and short-term prognosis after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. Methods 151 patients with acute myocardial infarction after PPCI were enrolled in this study. Those patients were admitted to our hospital during January 2017 to January 2018. According to the numerical randomization method, 51 patients were selected as routine treatment group (group A), 50 patients with intracoronary injection of nicorandil (group B) and 50 patients received intracoronary injection of nicorandil plus oral Shexiang Baoxin pills (group C). Intra-operative corrected TIMI frame count (cTFC), postoperative TIMI grade 3 blood flow ratio, 2-hour ECG ST segment fallback >50% index, the incidence of major adverse cardiovascular events (MACE) during hospitalization and the incidence of angina and MACE within 3 months after surgery were evaluated. Results cTFC, 2 hours postoperative ECG ST segment fall >50% index in group B and C were better than group A (P<0.05). The results from group C were better than group B. Group C exhibited better results than group B and C in post-operative angina pectoris 3 months after surgery (P<0.05). Conclusion Shexiang Baoxin pills combined with intra-coronary injection of nicorandil can improve myocardial perfusion and short-term prognosis after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
