Study on quality standard of compound Yuhong suppository
10.12206/j.issn.1006-0111.202103003
- VernacularTitle:复方玉红栓的质量标准研究
- Author:
Yeshuai HU
1
;
Xiaomeng TANG
1
;
Zhijun WANG
1
;
Yueying HUANG
1
;
Xiaojun WANG
1
;
Hongjie SONG
1
Author Information
1. Department of Pharmacy, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
- Keywords:
compound Yuhong suppository;
Angelica dahurica;
colophony;
Sophora flavescens Alt.;
sulfadiazine;
dyclonine hydrochloride
- From:
Journal of Pharmaceutical Practice
2022;40(1):76-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the quality standard of compound Yuhong suppository. Methods Angelica dahurica, colophony and Sophora flavescens Alt. were identified by thin layer chromatography（TLC）method. The contents of sulfadiazine and dyclonine hydrochloride were determined by HPLC with diode array detection method. The mobile phase was methanol-0.02 mol/L potassium dihydrogen phosphate (adjusted to pH 3.3 with phosphoric acid) for gradient elution. The detection wavelength was 280 nm for sulfadiazine and dyclonine hydrochloride. Results The three Chinese traditional medicines were identified by TLC with clear spots. The linear ranges of sulfadiazine and dyclonine hydrochloride were good in 12.40-99.20 μg/ml (r=0.999 9) and 2.56-20.48 μg/ml (r=0.999 9). The average recovery was (99.21±0.43) % (n=9) and (99.54±0.68) % (n=9). Conclusion This method is accurate, sensitive, and reproducible. It can be used as a standard method for the quality control of compound Yuhong suppository.
