In vitro release study on self-microemulsion of curcumin and piperine
10.12206/j.issn.1006-0111.202009090
- VernacularTitle:复方自微乳中姜黄素和胡椒碱的体外释放研究
- Author:
Jinmei REN
1
;
Man LI
1
;
Jing WANG
1
;
Shenyong GU
1
Author Information
1. Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China.
- Keywords:
curcumin;
piperine;
self-microemulsifying drug delivery;
in vitro release;
sustained release
- From:
Journal of Pharmaceutical Practice
2022;40(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the release profile of curcumin and piperine from the compound self-microemulsion. Methods The release of curcumin and piperine in vitro was investigated by dynamic dialysis under the condition of phosphate buffer of pH 4.8 and 7.5 with 0.75% Tween-80. Results The cumulative release rates of curcumin in pH 4.8 and pH 7.5 were 94.85% and 84.38% in 108 h, respectively. The cumulative release rates of piperine were 92.85% and 90.05% in 36 h, separately. Conclusion Curcumin and piperine in self-microemulsion have sustained release properties and released more in the acidic environment similar to the environment in tumors.
