The research progress on the basic characteristics and metabolic regulation of α1-acid glycoprotein
10.12206/j.issn.1006-0111.202105032
- VernacularTitle:α1-酸性糖蛋白基本特征及代谢调节作用的研究进展
- Author:
Kefa XIANG
1
;
Jingjing WAN
2
;
Huimin ZHANG
1
;
Xiaofei SHI
1
;
Zhen QIN
1
;
Xia LIU
1
Author Information
1. Department of Clinical Pharmacy, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. Shanghai JiaoTong University, Shanghai 200030, China.
- Keywords:
alpha 1-acid glycoprotein;
metabolic;
structural characteristics;
biochemical characteristics
- From:
Journal of Pharmaceutical Practice
2022;40(1):6-11
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic homeostasis is a basic function necessary for the survival of the organism. α1-acid glycoprotein (AGP) is an acute phase protein with a glycosylation degree of up to 45%. It has high affinity and low capacity. Although the biological role of AGP is not fully understood, it has been proven that it can regulate immunity and metabolism, and play an important role in transporting drugs and maintaining capillary barrier function. In this review, the structural characteristics, biochemical characteristics and the regulation of AGP expression were reviewed, with emphasis on the regulatory role of AGP in metabolism, suggesting that AGP may be a potential key factor in metabolic pathways, which provides a new research direction for metabolic diseases.
