Freeze-dried rabies vaccine followed by death due to septic shock： a case report
10.19428/j.cnki.sjpm.2021.20830
- VernacularTitle:1例疑似接种狂犬疫苗发生脓毒性休克死亡病例的调查
- Author:
Li-li ZHANG
1
;
Xiang-qing WU
1
;
Chang-lei ZHANG
1
Author Information
1. Xiangcheng Center for Disease Control and Prevention， Suzhou， Jiangsu 215000， China
- Publication Type:Journal Article
- Keywords:
freeze-dried rabies vaccine （Vero cells） for human use;
sepsis;
septic shock;
coincidental event
- From:
Shanghai Journal of Preventive Medicine
2021;33(12):1206-1208
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze a case of death after inoculation of a freeze-dried rabies vaccine for human use so as to provide reference for the vaccination of the rabies vaccine and the process of investigation and diagnosis involving adverse events following immunization （AEFI） in the future. MethodsData on vaccination， clinical symptoms， treatments， investigation and diagnosis were collected and analyzed. ResultsRabies post-exposure prophylaxis and vaccination were in line with the protocols. On the 3rd day after the inoculation of the rabies vaccine， the patient developed fever， weakness， headache， dizziness， diarrhea and other symptoms. The white blood cell count and neutrophil count increased progressively. At about 17：00 on the same day， the patient suffered a sudden cardiac arrest and died clinically. Autopsy was not carried out. ConclusionThe cause of sepsis /septic shock of the patient is unknown. It is necessary to formulate detailed rabies immunization procedures as well as norms and expert consensus in the field of investigation and diagnosis of AEFI.
