Effect of comprehensive intervention on ANGPTL2 and vascular endothelial function in obese male adolescents
10.16835/j.cnki.1000-9817.2021.12.031
- VernacularTitle:综合干预对肥胖男性青少年血管生成素样蛋白2和血管内皮功能的影响
- Author:
YAO Meng, TANG Donghui, BAI Shuang
1
Author Information
1. College of P.E. and Sports Science, Beijing Normal University, Beijing (100875), China
- Publication Type:Journal Article
- Keywords:
Obesity;
Angiopoietin-2;
Cardiovascular system;
Adolescent;
Male
- From:
Chinese Journal of School Health
2021;42(12):1888-1891
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of a comprehensive exercise intervention program combined with diet control on ANGPTL2 and vascular endothelial function in obese male adolescents, and to provide theoretual basis for exercise to reduce the risk of cardiovascular disease in obese male adolescents.
Methods:Forty two obese male adolescents and 10 healthy male adolescents were selected, a comprehensive intervention of 6 weeks of exercise combined with diet control was carried out on obese male adolescents, and changes in morphological function, glucose and lipid metabolism, inflammation level and vascular endothelial function were measured before and after the intervention.
Results:After 6 weeks of comprehensive intervention, the morphological and functional indicators of obese adolescents were significantly reduced:weight, BMI, waist circumference, waist to hip ratio, systolic blood pressure, diastolic blood pressure ( P <0.05); blood lipid levels significantly decreased, including TC, TG and LDL-C ( P <0.05); inflammation levels significantly decreased, including TNF α and ANGPTL2 ( P <0.05); Vascular endothelial function significantly improved:RHI, NO/ET-1, NO, AI( P <0.05). Before and after 6 weeks of comprehensive intervention, the ANGPTL2 of obese adolescents was significantly correlated with weight ( r =0.37), BMI ( r =0.45), RHI ( r =-0.46), NO/ET-1 ( r =-0.41), NO( r =-0.45), and AI ( r =0.33)( P <0.05).
Conclusion:The comprehensive intervention can effectively improve the morphological function, blood lipid level and vascular endothelial function of obese male adolescents, and reduce the circulating level of ANGPTL2. ANGPTL2 may be involved in the process of comprehensive intervention to improve the vascular endothelial function of obese adolescents.
