Prevalence of hepatitis B virus infection and residual transmission risk among volunteer blood donors in Hangzhou City
10.19485/j.cnki.issn2096-5087.2022.01.013
- Author:
ZHU Hong
;
DONG Jie
;
LING Xia
;
LI Xiaotao
;
WU Danxiao
;
ZHU Faming
- Publication Type:Journal Article
- Keywords:
volunteer blood donor；hepatitis B virus；residual risk；nucleic acid testing
- From:
Journal of Preventive Medicine
2022;34(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the prevalence of hepatitis B virus ( HBV ) infection among volunteer blood donors in Hangzhou City, and to evaluate the residual risk of transfusion-transmitted HBV infections.
Methods :Data pertaining to volunteer blood donors in Hangzhou City from 2016 to 2019 were retrieved from the blood donor management system. Hepatitis B surface antigen ( HBsAg ) was detected by enzyme-linked immunosorbent assay ( ELISA ) and HBV DNA was detected using nucleic acid testing. The incidence/window period model was employed to assess the residual risk of HBV transmitted through transfusion from donors.
Results :The prevalence of HBV infections was 0.56% among the 320 755 first-time donors and 0.13% among the 279 816 repeat donors in Hangzhou City from 2016 to 2019, and a higher prevalence of HBV infection was detected among first-time donors than among repeat donors ( P<0.05 ). The residual risks of transfusion-transmitted HBV infection were 296.38 per million person-times ( 95%CI: 277.57 to 315.19 per million person-times ) and 98.79 per million person-times ( 95%CI: 87.15 to 110.43 per million person-times ) among first-time and repeat donors with positive HBsAg, and were 86.79 per million person-times ( 95%CI: 76.60 to 96.98 per million person-times ) and 28.93 per million person-times ( 95%CI: 22.63 to 35.23 per million person-times ) among first-time and repeat donors tested positive for HBV DNA, respectively.
Conclusions :There is still a residual risk of HBV infection transmitted through transfusion from blood donors in Hangzhou City. Nucleic acid testing may remarkably reduce the residual risk of transfusion-transmitted HBV infection in blood donors.
- Full text:杭州市无偿献血者乙型肝炎病毒感染及其传播残余风险分析.pdf
