Predictive effect of inflammatory biomarkers on prognosis of liver transplantation for hepatocellular carcinoma
10.3969/j.issn.1674-7445.2022.01.008
- VernacularTitle:炎症生物标志物对肝癌肝移植预后的预测作用
- Author:
Yishan NIU
1
;
Qiang ZENG
Author Information
1. Department of Hepatobiliary Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
- Publication Type:Research Article
- Keywords:
Hepatocellular carcinoma;
Liver transplantation;
Inflammatory biomarker;
Tumor recurrence;
Neutrophil-to-lymphocyte ratio (NLR);
Platelet-to-lymphocyte ratio (PLR);
Glasgow prognostic score (GPS);
Prognostic nutritional index (PNI)
- From:
Organ Transplantation
2022;13(1):49-
- CountryChina
- Language:Chinese
-
Abstract:
Tumor recurrence is the main issue that affects the long-term survival of recipients after liver transplantation for hepatocellular carcinoma. Accurate preoperative evaluation and proper selection of transplant recipients are the key factors affecting the long-term prognosis of recipients undergoing liver transplantation for hepatocellular carcinoma. Neutrophil, lymphocyte, C-reactive protein, platelet and fibrinogen (FIB) are major biomarkers that indicate inflammatory response of the host. Multiple studies have found that these biomarkers may not only represent the inflammatory response, but also could be integrated to predict tumor recurrence and long-term survival rate of the recipients following liver transplantation for hepatocellular carcinoma. These biomarkers mainly consist of neutrophil-to-lymphocyte ratio (NLR), Glasgow prognostic score (GPS), FIB, platelet-to-lymphocyte ratio (PLR) and prognostic nutritional index (PNI), etc. In this article, research progresses on predictive effect of inflammatory biomarkers on prognosis of liver transplantation for hepatocellular carcinoma were reviewed.
