Normothermic machine perfusion of kidney and ischemia-free kidney transplantation
10.3969/j.issn.1674-7445.2022.01.005
- VernacularTitle:肾脏常温机械灌注与无缺血肾移植
- Author:
Guobin WU
1
;
Guodong CHEN
Author Information
1. Organ Transplantation Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
- Publication Type:Research Article
- Keywords:
Organ preservation;
Normothermic machine perfusion (NMP);
Normothermic regional perfusion (NRP);
Static cold storage (SCS);
Ischemia-free kidney transplantation (IFKT);
Expanded criteria donor (ECD);
Neutrophil gelatinase-associated lipocalin (NGAL);
Kidney injury molecule-1 (KIM-1)
- From:
Organ Transplantation
2022;13(1):32-
- CountryChina
- Language:Chinese
-
Abstract:
To increase the utilization rate of expanded criteria donor (ECD) kidney, the kidney preservation methods have been ever advancing in recent years. The application of normothermic machine perfusion (NMP) promotes the preservation, evaluation and repair of ex vivo donor kidneys and accelerates the innovation of surgical approaches of kidney transplantation. Ischemia-free kidney transplantation (IFKT), which initiated by Organ Transplantation Center of the First Affiliated Hospital of Sun Yat-sen University, keeps the blood flow and oxygen supply of the donor kidney with NMP machine during the entire process of acquisition, preservation and transplantation, thereby fundamentally avoiding ischemia-reperfusion injury (IRI) of the donor kidney and reducing the risk of delayed graft function (DGF) and acute rejection after surgery. In this article, recent progresses upon the kidney NMP, surgical procedures and short-term outcomes of IFKT were reviewed, aiming to provide reference for enhancing the utilization rate of ECD donor kidney and resolving the issue of organ shortage.
