Research progress on the mechanism of iridoids from Gardenia jasminoides against Alzheimer ’s disease
- VernacularTitle:栀子中环烯醚萜类成分抗阿尔茨海默病的作用机制研究进展
- Author:
Qing FU
1
;
Qi SHAN
2
,
3
,
4
;
Yutong ZHOU
2
,
3
,
4
;
Bing YANG
2
,
3
,
4
;
Yuming YUE
1
;
Yuanqi JIANG
1
;
Fujun ZHOU
2
,
3
Author Information
1. Graduate School，Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China
2. State Key Laboratory of Drug Release Technology and Pharmacokinetics，Tianjin 300301，China
3. Tianjin Key Laboratory of Quality Markers of Traditional Chinese Medicine，Tianjin 300301，China
4. Tianjin Institute of Pharmaceutical Research，Tianjin 300301，China
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
Gardenia jasminoides;
iridoids;
geniposide;
mechanism
- From:
China Pharmacy
2022;33(1):123-128
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer’s disease （AD）is a common latent neurodegenerative disease ，which is characterized by cognitive impairment，loss of learning and memory function ，abnormal behavior and dementia. At present ，there is no specific drug to effectively prevent or reverse AD. Gardenia jasminoides is the dried and mature fruit of G. jasminoides J. Ellis ，a gardenia plant in Rubiaceae. Its chemical components mainly include iridoids ，triterpenoids，organic acids and volatile oils ，among which iridoids are the main active components of G. jasminoides . This paper summarizes the researches on the mechanism of iridoids from G. jasminoides against AD at home and abroad in recent years ，in order to provide reference for the development of new drugs against AD.
