Study on the quality standard of Kuipingning gastric floating tablets
- VernacularTitle:溃平宁胃漂浮片的质量标准研究
- Author:
Baocai WANG
1
;
Guoduo LI
2
Author Information
1. Center for Scientific Research Preparation，Gansu Provincial Hospital of TCM，Gansu Baiyin 730900，China
2. Dept. of Clinical Laboratory，Gansu Provincial Hospital of TCM，Lanzhou 730050，China
- Publication Type:Journal Article
- Keywords:
Kuipingning gastric floating tablets;
quality standard;
total anthraquinones in Rheum palmatum;
release kinetics
- From:
China Pharmacy
2022;33(1):69-73
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish the quality standard of Kuipingning gastric floating tablets. METHODS Kuipingning gastric floating tablets were prepared and investigated in terms of property ，weight difference and friability. Crydalis yanhusuo was identified qualitatively by thin layer chromatography （TLC）method. High performance liquid chromatography method was used to determine the content of total anthraquinones in Rheum palmatum ，and set the content limit of total anthraquinones. The floating performance and release degree of the preparation were investigated ，and the release kinetic process was fitted. RESULTS Kuipingning gastric floating tablets prepared in this study were gray white to gray tablets with slight smell and bitter taste ；the weight difference and friability were all in line with relevant regulations ；the established TLC method possessed strong specificity and could accurately identify C. yanhusuo . The average content of total anthraquinones in R. palmatum was 17.95 mg/tablet，and its content limit would not be less than 14.36 mg/tablet. The initial floating time of the preparation was no more than 10 s，and the holding time was more than 8 h. The release kinetics process accorded with the Retger-Peppas release model. CONCLUSIONS The method established in this study shows good reliability ，stability and feasibility ，and can effectively control the quality of Kuipingning gastric floating tablets.
