Meta analysis of the relationship between the neutrophils/lymphocytes ratio and prognosis in patients with oral squamous cell carcinoma
10.12016/j.issn.2096-1456.2022.03.006
- Author:
ZHANG Wen
1
,
2
;
ZOU Bo
1
,
2
;
LIU Jianlin
1
,
2
;
YUAN Daoying
1
,
2
Author Information
1. Department of Stomatology, Liaocheng People&rsquo
2. s Hospital
- Publication Type:Journal Article
- Keywords:
oral squamous cell carcinoma;
neutrophil to lymphocyte ratio;
extranodal extension;
overall survival;
disease free survival;
disease specific survival;
peripheral nerve invasion;
Meta analysis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2022;30(3):191-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To clarify the prognostic value of the neutrophil to lymphocyte ratio (NLR) in oral squamous cell carcinoma (OSCC) patients.
Methods:literature on the correlation between NLR and the prognosis and clinicopathological features of OSCC was searched in PubMed, Web of Science, Cochrane and Embase. The outcome indicators, including overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), tumor size, cervical lymph node metastasis, tumor stage, extracapsular lymph node invasion and peripheral nerve invasion, were analyzed by RevMan5.3 software
Results : In total, 6 180 patients were included in 23 studies. The analysis showed that NLR was significantly negatively correlated with OS [HR=1.62, 95%CI(1.38, 1.91), P < 0.001], DFS [HR=1.48, 95%CI(1.24, 1.77), P < 0.001] and DSS [HR=1.87, 95%CI(1.60, 2.20), P < 0.001]. In addition, higher NLR values were positively correlated with tumor size [OR=2.68, 95%CI (1.84, 3.90), P < 0.001], cervical lymph node metastasis [OR=1.59, 95%CI (1.35, 1.88), P < 0.001], tumor stage [OR=2.85, 95%CI (2.35, 3.47), P < 0.001], extralymphatic invasion [OR=1.72, 95%CI (1.23, 2.40), P=0.001], and peripheral nerve invasion [OR=1.70, 95%CI (1.29, 2.24), P < 0.001]. However, there was no significant correlation with age [OR=0.96, 95%CI (0.71, 1.29), P=0.77], sex [OR=1.08, 95%CI (0.88, 1.33), P=0.55], or degree of differentiation [OR=1.15, 95%CI (0.92, 1.43), P=0.22]
Conclusion :Elevated NLR was significantly associated with the prognosis and clinicopathological features of OSCC and might be an independent prognostic factor.
- Full text:中性粒细胞_淋巴细胞比值与口腔鳞状细胞癌预后相关性的Meta分析.pdf
