Role of leukemia inhibitory factor in pancreatic ductal adenocarcinoma
10.3969/j.issn.1001-5256.2021.12.053
- VernacularTitle:白血病抑制因子在胰腺导管腺癌中的作用
- Author:
Yaxing XIE
1
;
Chenguang SHI
1
;
Xiaohuan LIU
1
;
Yanbo MA
2
Author Information
1. The First Clinical Medical College of Shanxi Medical University, Taiyuan 030000, China
2. Department of General Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030000, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Pancreatic Ductal;
Leukemia Inhibitory Factor;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2021;37(12):2986-2989
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic ductal adenocarcinoma is a highly invasive malignant tumor of the digestive system with an extremely poor prognosis. Leukemia inhibitory factor is an important member of the interleukin-6 family and can regulate multiple physiological processes such as cell differentiation, growth, and renewing. This article reviews the mechanism of action of leukemia inhibitory factor in pancreatic ductal adenocarcinoma and the research advances in leukocyte inhibitory factor-targeted therapy based on literature evidence, and the analysis shows that leukemia inhibitory factor plays an important role in the progression, immune escape, and chemotherapy resistance of pancreatic ductal adenocarcinoma and may gradually become a potential biomarker and therapeutic target for pancreatic ductal adenocarcinoma.
