Association between immunoglobulin G4-related diseases and autoimmune hepatitis
10.3969/j.issn.1001-5256.2021.12.050
- VernacularTitle:IgG4相关性疾病与自身免疫性肝炎的关系
- Author:
Lili ZHANG
1
;
Aiwen GENG
1
;
Chuanwang QI
1
;
Jianchun XIAN
1
Author Information
1. Department of Hepatopathy, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China
- Publication Type:Reviews
- Keywords:
Immunoglobulin G;
Hepatitis, Autoimmune;
Autoimmune Diseases
- From:
Journal of Clinical Hepatology
2021;37(12):2972-2975
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement in people's awareness of diseases and the level of diagnosis and treatment, the incidence rates of immunoglobulin G4-related disease (IgG4-RD) and autoimmune liver disease (AILD) are constantly increasing, and IgG4-related sclerosing cholangitis is the overlapping part of the disease spectrum of IgG4-RD and AILD, while the association between IgG4-related autoimmune hepatitis (IgG4-AIH) and these two diseases remains unclear. This article reviews the hepatic manifestation of IgG4-RD, summarizes the clinical features of IgG4-AIH, and analyzes whether IgG4-AIH is a subtype of AIH or a hepatic involvement of IgG4-RD. It is believed that IgG4-AIH has similar but different clinical manifestations and histopathological features from classical AIH, and IgG4-AIH may be classified as two types, i.e., a subtype of AIH and the liver manifestation of IgG4-RD. The research on the pathogenesis, clinical features, and clinical diagnosis and treatment of IgG4-AIH should be taken seriously in future.
